AC-186

AC-186 is a non-steroidal estrogen receptor beta (ERbeta) agonist (EC50 = 6 nM in a functional assay). It is selective for ERbeta over ERalpha (EC50 = 5,000 nM). AC-186 (10 mg/kg) reduces dopaminergic neuronal loss in the substantia nigra, improves novel object recognition, and improves motor performance in male, but not female, rats in a model of Parkinson's disease induced by 6-OHDA (Cay-25330). It reduces tactile allodynia in male, but not female or female ovariectomized, rats in a model of spinal nerve ligation-induced neuropathic pain. AC-186 (10 and 30 mg/kg) also reduces tactile allodynia in male rats in a model of neuropathic pain induced by paclitaxel (Cay-10461).Formal Name: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]-phenol. CAS Number: 1421854-16-1. Molecular Formula: C18H17F3O. Formula Weight: 306.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 230 nm. SMILES: FC1(F)CCC(C2=CC=C(O)C=C2)(C3=CC=CC=C3F)CC1. InChi Code: InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2. InChi Key: HSMUKSLNDJOZQG-UHFFFAOYSA-N.