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ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C- adrenergic receptors (Kis = 890, 597, and 342 nM, respectively), and 70 other receptors, enzymes, and transporters (Kis = >1,000 nM) in radioligand binding assays. ABT-594 induces [86Rb+] efflux in K177 cells transfected with human neuronal alpha4beta2 subunit-containing nAChRs (EC50 = 140 nM). In vivo, ABT-594 (0.05 and 0.01 mg/kg, s.c.) increases latency to paw withdrawal in a hot-plate test in rats. It also induces hypothermia, seizures, and an increase in blood pressure.Formal Name: 5-[(2R)-2-azetidinylmethoxy]-2-chloro-pyridine, monohydrochloride. CAS Number: 203564-54-9. Synonyms: Ebanicline, Tebanicline. Molecular Formula: C9H11ClN2O . HCl. Formula Weight: 235.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=CC=C(OC[C@@H]2NCC2)C=N1.Cl. InChi Code: InChI=1S/C9H11ClN2O.ClH/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7,/h1-2,5,7,11H,3-4,6H2,1H/t7-,/m1./s1. InChi Key: GYVARJONEFSAJB-OGFXRTJISA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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