ABT-100

ABT-100 is an inhibitor of farnesyltransferase (FTase). It inhibits Ras farnesylation but not Rap1A geranylgeranylation in HepG2 and Huh7 cells when used at a concentration of 20 µM. ABT-100 (2-20 µM) inhibits the proliferation of the same cells. In vivo, ABT-100 (39 mg/kg per day) increases body weight and percent survival, improves grip strength, and decreases the number of rib fractures in a Zmpste24-/- mouse model of progeria.Formal Name: 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbonitrile. CAS Number: 450839-40-4. Synonyms: A-367074. Molecular Formula: C27H19F3N4O3. Formula Weight: 504.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: FC(F)(OC1=CC=C(C2=C(OC[C@](C3=CC=C(C#N)C=C3)(C4=CN=CN4C)O)C=CC(C#N)=C2)C=C1)F. InChi Code: InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1. InChi Key: HEUVRFNVTLGKMZ-SANMLTNESA-N.