ABP 688

ABP 688 is a non-competitive antagonist of metabotropic glutamate receptor 5 (mGluR5, Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors). It is selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 µM. ABP 688 inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively). Radiolabeled forms of ABP 688 have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents.Formal Name: 3-[2-(6-methyl-2-pyridinyl)ethynyl]-2-cyclohexen-1-one, O-methyloxime. CAS Number: 924298-51-1. Molecular Formula: C15H16N2O. Formula Weight: 240.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: 100 mM. SMILES: CC1=CC=CC(C#CC(CCC/2)=CC2=N\OC)=N1. InChi Code: InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3/b17-15+. InChi Key: CNNZLFXCUQLKOB-BMRADRMJSA-N.