AA43279

AA43279 is an activator of voltage-gated sodium channel 1.1 (Nav1.1, EC50 = 9.5 µM in a patch-clamp assay using HEK293 cells expressing the human channel). It is selective for Nav1.1 over Nav1.4 and Nav1.7 at 30 µM but also activates Nav1.2, Nav1.5, and Nav1.6 (EC50s = 22.8, 14.4, and 11.6 µM, respectively). AA43279 also inhibits IkappaB kinase beta (IKKbeta, IC50 = 2.9 µM). It increases the seizure threshold in the maximal electroshock seizure threshold (MEST) test in mice when administered at a dose of 300 mg/kg.Formal Name: 3-amino-5-(4-methoxyphenyl)-2-thiophenecarboxamide. CAS Number: 354812-16-1. Molecular Formula: C12H12N2O2S. Formula Weight: 248.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: O=C(C1=C(N)C=C(C2=CC=C(C=C2)OC)S1)N. InChi Code: InChI=1S/C12H12N2O2S/c1-16-8-4-2-7(3-5-8)10-6-9(13)11(17-10)12(14)15/h2-6H,13H2,1H3,(H2,14,15). InChi Key: OEUITKOCUWEFOB-UHFFFAOYSA-N.