A23187

A23187 is a calcium ionophore and a microbial metabolite that has been found in S. chartreusensis. It induces calcium overload and mitochondrial apoptosis in HEK293 cells when used at a concentration of 5 µM. A23187 (5 µM) induces the production of reactive oxygen species (ROS) and neutrophil extracellular trap (NET) formation in primary human neutrophils in a myeloperoxidase-, neutrophil elastase-, and citrullination-independent manner.Formal Name: 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl-4-benzoxazolecarboxylic acid. CAS Number: 52665-69-7. Synonyms: Calcimycin. Molecular Formula: C29H37N3O6. Formula Weight: 523.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 1 mg/ml. lambdamax: 226, 279, 379 nm. SMILES: O=C([C@@H](C)[C@]1([H])[C@H](C)C[C@@H](C)[C@@]2(O[C@H](CC3=NC(C(C(O)=O)=C(NC)C=C4)=C4O3)[C@H](C)CC2)O1)C5=CC=CN5. InChi Code: InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1. InChi Key: HIYAVKIYRIFSCZ-CYEMHPAKSA-N. Origin: Bacterium/Streptomyces chartreusis.