A23187 (calcium magnesium salt)

A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways. A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.Formal Name: 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, calcium salt (2:1) 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, magnesium salt (2:1). Synonyms: Calcimycin. Molecular Formula: [C29H36N3O6]2 Ca . [C29H36N3O6]2 Mg. Formula Weight: 2154.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, Ethanol: 3 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 230, 303, 371 nm. SMILES: O=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC=C1NC)[O-].O=C(C6=C7N=C(C[C@H]8O[C@]9(O[C@H]([C@H](C)C(C%10=CC=CN%10)=O)[C@H](C)C[C@H]9C)CC[C@H]8C)OC7=CC=C6NC)[O-].O=C(C%11=C%12N=C(C[C@H]%13O[C@]%14(O[C@H]([C@H](C)C(C%15=CC=CN%15)=O)[C@H](C)C[C@H]%14C)CC[C@H]%13C)OC%12=CC=C%11NC)[O-].O=C(C%16=C%17N=C(C[C@H]%18O[C@]%19(O[C@H]([C@H](C)C(C%20=CC=CN%20)=O)[C@H](C)C[C@H]%19C)CC[C@H]%18C)OC%17=CC=C%16NC)[O-].[Ca+2].[Mg+2]. InChi Code: InChI=1S/4C29H37N3O6.Ca.Mg/c4*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35,,/h4*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35),,/q,,,,2*+2/p-4/t4*15-,16-,17-,18-,22-,27+,29+,,/m1111../s1. InChi Key: QAKUEZRADAKQMD-FDZCDQLOSA-J.