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Description: A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation. Target: Epigenetic Reader Domain, PROTACs. Smiles: C(#N)[C@]1([C@H]([C@H](C(NC2=C(OC)C=C(C(NCCOCCOCCO CCNC(C[C@H]3C=4N(C5=C(C(=N3)C6=CC=C(Cl)C=C6)C(C)=C(C)S5)C(C)=NN4)=O)=O)C=C2)=O)N[C@H]1CC(C)(C)C)C7=C(F)C(Cl)=CC=C7)C8=C(F)C=C(Cl)C=C8. References: Hines J, Lartigue S, Dong H.et.al.MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53[J].Cancer Res. 2019 Jan 1,79(1):251-262.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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