A-943931 (hydrochloride hydrate)

A-943931 is a histamine H4 receptor antagonist (Ki = 3.8 nM). In vivo, A-943931 inhibits scratching induced by clobenpropit (Cay-10011126) in mice (ED50 = 26 µmoles/kg, i.p.).Formal Name: 4-[(3R)-3-amino-1-pyrrolidinyl]-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine, dihydrochloride, hydrate. Molecular Formula: C17H21N5 . 2HCl [XH2O]. Formula Weight: 368.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: NC1=NC(N2CC[C@H](C2)N)=C(CCCC3=CC=CC=C34)C4=N1.O.Cl.Cl. InChi Code: InChI=1S/C17H21N5.2ClH.H2O/c18-12-8-9-22(10-12)16-14-7-3-5-11-4-1-2-6-13(11)15(14)20-17(19)21-16,,,/h1-2,4,6,12H,3,5,7-10,18H2,(H2,19,20,21),2*1H,1H2/t12-,,,/m1.../s1. InChi Key: FIZFLIYBVYYMAI-CSIATVMVSA-N.