A-771726

A-771726 is an active metabolite of the prodrug leflunomide (Cay-14860) that inhibits dihydroorotate dehydrogenase (DHODH, IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2, Cay-14010) in TNF-alpha- or IL-1alpha-stimulated isolated human synoviocytes (IC50s = 7 and 3 µM, respectively). It inhibits the proliferation of isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 25 and 100 µM. A-771726 (3 and 10 mg/kg) delays disease onset and decreases neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by complete Freund's adjuvant (CFA) and M. tuberculosis. Formulations containing teriflunomide have been used in the treatment of multiple sclerosis.Formal Name: 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide. CAS Number: 163451-81-8. Synonyms: Flucyamide, HMR 1726, SU 20, Teriflunomide. Molecular Formula: C12H9F3N2O2. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 21.6 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10.7 mg/ml. lambdamax: 203, 251, 288 nm. SMILES: O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1. InChi Code: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-. InChi Key: UTNUDOFZCWSZMS-YFHOEESVSA-N.