A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-car

A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the B1 subunit. A-769662 activates AMPK through the beta subunit carbohydrate-binding module and the gamma subunit but not the AMP-binding sites. Solubility: Soluble in DMSO at 33mg/ml, soluble in ethanol at 5mg/ml with slight warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 50-100uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. , Melting Point: 277-280ºC, Elemental Analysis: Calculated, C: 64.25%, H: 3.64%, N: 7.49%, S: 8.58%, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.