7ACC2

7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells. It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria. In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.Formal Name: 7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid. CAS Number: 1472624-85-3. Molecular Formula: C18H15NO4. Formula Weight: 309.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 204, 256, 416 nm. SMILES: CN(C1=CC=C(C=C(C(O)=O)C(O2)=O)C2=C1)CC3=CC=CC=C3. InChi Code: InChI=1S/C18H15NO4/c1-19(11-12-5-3-2-4-6-12)14-8-7-13-9-15(17(20)21)18(22)23-16(13)10-14/h2-10H,11H2,1H3,(H,20,21). InChi Key: XTKDQPFUOFAMRL-UHFFFAOYSA-N.