(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine (Cay-13956). THFA has also been used to study the activation of metabolite-binding riboswitches.Formal Name: N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, trihydrochloride. CAS Number: 150731-85-4. Synonyms: Tetrahydrofolate, THFA. Molecular Formula: C19H23N7O6 . 3HCl. Formula Weight: 554.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 276 nm. SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N2)NC(N)=N1.Cl.Cl.Cl. InChi Code: InChI=1S/C19H23N7O6.3ClH/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28,,,/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30),3*1H/t11?,12-,,,/m0.../s1. InChi Key: PODZJLOKQRGHJH-WMBFYOGGSA-N.