6-thio-2'-Deoxyguanosine

6-thio-2'-Deoxyguanosine (6-thio-dG) is a purine nucleoside analog. It reduces infection of Calu-3 cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, EC50 = 0.04 µM) but is also toxic to Calu-3 cells with a 50% cytotoxic concentration (CC50) value of 1.14 µM. 6-Thio-dG (2 mg/kg) decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 non-small cell lung cancer (NSCLC) mouse xenograft model. It increases the number of programmed cell death protein 1 (PD-1) positive CD8+ T cells, as well as induces tumor regression when administered in combination with an antibody against PD-1 ligand (PD-L1) in MC-38 murine colon carcinoma models.Formal Name: 2'-deoxy-6-thio-guanosine. CAS Number: 789-61-7. Synonyms: 6-thio-dG, NSC 71261, beta-Thioguanine deoxyriboside. Molecular Formula: C10H13N5O3S. Formula Weight: 283.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 20 mg/ml. lambdamax: 209, 259, 346 nm. SMILES: O[C@H]1C[C@H](N2C=NC3=C2N=C(N)NC3=S)O[C@@H]1CO. InChi Code: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1. InChi Key: SCVJRXQHFJXZFZ-KVQBGUIXSA-N.