6-hydroxy Buspirone
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay39807-1 | 1 mg | - |
6 - 10 business days* |
314.00€
|
|||
| Cay39807-5 | 5 mg | - |
6 - 10 business days* |
1,329.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
6-hydroxy Buspirone is an active metabolite of the anxiolytic buspirone. It is formed from... more
Product information "6-hydroxy Buspirone"
6-hydroxy Buspirone is an active metabolite of the anxiolytic buspirone. It is formed from buspirone by the cytochrome P450 (CYP) isoform CYP3A4. 6-hydroxy Buspirone binds to the serotonin (5-HT) receptor subtype 5-HT1A in rat hippocampus and dorsal raphe (EC50s = 4 and 1 µM, respectively) and is a dopamine D2, D3, and D4 receptor antagonist (IC50s = 3.1, 4.9, and 0.85 µM, respectively). It also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 in S2 proximal tubule cells expressing the human transporters in a concentration-dependent manner.Formal Name: 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione. CAS Number: 125481-61-0. Synonyms: BMS-52821, BMY 28674. Molecular Formula: C21H31N5O3. Formula Weight: 401.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: OC(C(N1CCCCN2CCN(CC2)C3=NC=CC=N3)=O)C4(CC1=O)CCCC4. InChi Code: InChI=1S/C21H31N5O3/c27-17-16-21(6-1-2-7-21)18(28)19(29)26(17)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9,18,28H,1-4,6-7,10-16H2. InChi Key: KOZNAHJIJGCFJJ-UHFFFAOYSA-N.
| Keywords: | BMS-52821, BMY 28674, 6-hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 39807 |
Properties
| Application: | Active buspirone metabolite |
| MW: | 401.5 D |
| Formula: | C21H31N5O3 |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 125481-61-0| Matching products |
| KEGG ID : | K17689 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H312, H315, H319, H332 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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