5-Methyluridine

Description: 5-Methyluridine (Thymine riboside) is an endogenous methylated nucleoside found in human fluids, methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls.DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. Target: Others, Endogenous Metabolite. Smiles: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(C)=C2. References: Morris GS, et al. Use of biological fluids for the rapid diagnosis of potentially lethal inherited disorders of human purine and pyrimidine metabolism. Biomed Chromatogr. 1986 Jun,1(3):109-18.