5-methoxy-DL-Tryptophan

5-methoxy-DL-Tryptophan (DL-5-MTP) is an active metabolite of tryptophan with anti-inflammatory and anticancer activities. It reduces LPS-induced expression of COX-2, TNF-alpha, IL-1beta, and IL-6 in RAW 264.7 macrophages when used at a concentration of 50 mM. DL-5-MTP (23.4 mg/kg) increases survival in a mouse model of LPS-induced endotoxemia and a mouse model of sepsis induced by cecal ligation and puncture. It also reduces tumor growth and the number of metastases in an A549 mouse xenograft model when administered at a dose of 100 mg/kg.Formal Name: 5-methoxy-tryptophan. CAS Number: 28052-84-8. Synonyms: DL-5-Methoxytryptophan, DL-5-MTP, 5-Methoxytryptophan. Molecular Formula: C12H14N2O3. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: NC(C(O)=O)CC1=CNC2=CC=C(OC)C=C21. InChi Code: InChI=1S/C12H14N2O3/c1-17-8-2-3-11-9(5-8)7(6-14-11)4-10(13)12(15)16/h2-3,5-6,10,14H,4,13H2,1H3,(H,15,16). InChi Key: KVNPSKDDJARYKK-UHFFFAOYSA-N.