5-(Hydroxymethyl)-2'-deoxycytidine

DNA methylation occurs mainly at the 5'-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2'-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.Formal Name: 2'-deoxy-5-(hydroxymethyl)-cytidine. CAS Number: 7226-77-9. Molecular Formula: C10H15N3O5. Formula Weight: 257.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 277 nm. SMILES: O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(CO)C(N)=N1. InChi Code: InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1. InChi Key: HMUOMFLFUUHUPE-XLPZGREQSA-N.