5-fluoro 203

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. 5-fluoro 203 is a cytotoxic compound that at 1 µM activates AhR signaling, inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest. In certain ovarian, breast, kidney, and colorectal cancer cells, 5-fluoro 203 can increase the levels of reactive oxygen species as well as activate JNK, ERK, and p38 MAPK.Formal Name: 4-(5-fluoro-2-benzothiazolyl)-2-methyl-benzenamine. CAS Number: 260443-89-8. Synonyms: NSC 703786. Molecular Formula: C14H11FN2S. Formula Weight: 258.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml. lambdamax: 204, 219, 351 nm. SMILES: FC1=CC=C(SC(C2=CC=C(N)C(C)=C2)=N3)C3=C1. InChi Code: InChI=1S/C14H11FN2S/c1-8-6-9(2-4-11(8)16)14-17-12-7-10(15)3-5-13(12)18-14/h2-7H,16H2,1H3. InChi Key: IFWLHIIUGSEKKE-UHFFFAOYSA-N.