5-Ethynyluridine

Description: 5-Ethynyluridine can be used to label newly synthesized RNA. This approach, named capture of the newly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs, including nascent RNAs and traditionally neglected nonpolyadenylated RNAs. Target: Nucleoside Antimetabolite/Analog. Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C#C)c(=O)[nH]c1=O. References: Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21,9(1):94.