5'-DEOXYADENOSINE

Description: 5'-Deoxyadenosine (5'-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar. Target: Endogenous Metabolite. Smiles: C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12. References: Lee S H , Jung B H , Kim S Y , et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection[J]. Rapid Communications in Mass Spectrometry, 2004, 18(9):973-977.