4-iodo-SAHA

4-iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. At 1 µM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA inhibits proliferation of SK-BR-3 breast-derived and HT29 colon-derived cell lines with EC50 values comparable to that of SAHA (1.1 and 0.95 µM versus 2.1 and 2 µM, respectively). It is 10-fold more potent as an inhibitor of U937 leukemia cell proliferation compared to SAHA (0.12 µM versus 1.2 µM, respectively).Formal Name: N1-hydroxy-N8-(4-iodophenyl) octanediamide. CAS Number: 1219807-87-0. Molecular Formula: C14H19IN2O3. Formula Weight: 390.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 255 nm. SMILES: IC1=CC=C(NC(CCCCCCC(NO)=O)=O)C=C1. InChi Code: InChI=1S/C14H19IN2O3/c15-11-7-9-12(10-8-11)16-13(18)5-3-1-2-4-6-14(19)17-20/h7-10,20H,1-6H2,(H,16,18)(H,17,19). InChi Key: BYVHZKAHBXINPL-UHFFFAOYSA-N.