4-Hydroxyphenylacetic Acid

4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory and anti-steatotic activities. It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota. 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-alpha, IL-1beta, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury. It reverses hepatic steatosis in a mouse model of high-fat diet-induced obesity when administered via a subcutaneous implant at a dose of 350 µg/day for two weeks. Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet. Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.Formal Name: 4-hydroxy-benzeneacetic acid. CAS Number: 156-38-7. Synonyms: 4-HPAA, p-HPAA, para-HPAA, p-Hydroxyphenylacetic Acid, para-Hydroxyphenylacetic Acid, NSC 25066, NSC 27460. Molecular Formula: C8H8O3. Formula Weight: 152.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC1=CC=C(CC(O)=O)C=C1. InChi Code: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11). InChi Key: XQXPVVBIMDBYFF-UHFFFAOYSA-N.