4-CPPC

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2, IC50 = 27 µM). It is selective for MIF-2 over MIF-1 (IC50 = 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.Formal Name: 4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid. CAS Number: 29553-70-6. Molecular Formula: C14H9NO6. Formula Weight: 287.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 223 nm. SMILES: OC(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)=O. InChi Code: InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21). InChi Key: NBVHLJGGHJLTGM-UHFFFAOYSA-N.