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4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2, IC50 = 27 µM). It is selective for MIF-2 over MIF-1 (IC50 = 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.Formal Name: 4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid. CAS Number: 29553-70-6. Molecular Formula: C14H9NO6. Formula Weight: 287.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 223 nm. SMILES: OC(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)=O. InChi Code: InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21). InChi Key: NBVHLJGGHJLTGM-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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