3-Iodotyrosine

3-Iodotyrosine is an inhibitor of tyrosine hydroxylase (Ki = 0.39 µM) and an intermediate in the synthesis of thyroid hormones. It has been incorporated into proteins as a non-natural amino acid for use as a label to detect protein-protein interactions. 3-Iodotyrosine induces the formation of alpha-synuclein aggregates and tyrosine hydroxylase-positive inclusions in primary substantia nigra neurons when used at concentrations of 5 and 10 nM. It induces parkinsonism in mice, reducing locomotor activity and inducing bradykinesia in the open field test when administered at an intrastriatal dose of 10 µM.Formal Name: 3-iodo-L-tyrosine. CAS Number: 70-78-0. Synonyms: 3-iodo-4-Hydroxyphenylalanine, Monoiodotyrosine, NSC 210787. Molecular Formula: C9H10INO3. Formula Weight: 307.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 0.15 mg/mL. lambdamax: 283 nm. SMILES: IC1=C(O)C=CC(C[C@H](N)C(O)=O)=C1. InChi Code: InChI=1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1. InChi Key: UQTZMGFTRHFAAM-ZETCQYMHSA-N.