3,5-Diiodo-L-thyronine

3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite. It binds to thyroid hormone receptor alpha1 (TRalpha1), TRbeta1, and TRbeta2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays). 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide. It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 µg/g per day.Formal Name: O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine. CAS Number: 1041-01-6. Synonyms: 3,5-Diiodothyronine, NSC 90469, 3,5-T2. Molecular Formula: C15H13I2NO4. Formula Weight: 525.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml. lambdamax: 229 nm. SMILES: IC(C=C(C=C1I)C[C@H](N)C(O)=O)=C1OC2=CC=C(C=C2)O. InChi Code: InChI=1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1. InChi Key: ZHSOTLOTTDYIIK-ZDUSSCGKSA-N.