3,3',5-Triiodo-L-thyronine (sodium salt hydrate)

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.Formal Name: O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, monosodium salt, hydrate. CAS Number: 345957-19-9. Synonyms: Liothyronine, T3, L-3,3',5-Triiodothyronine. Molecular Formula: C15H11I3NO4 . Na [XH2O]. Formula Weight: 673.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 227, 297 nm. SMILES: IC1=C(OC2=CC(I)=C(O)C=C2)C(I)=CC(C[C@@H](C([O-])=O)N)=C1.[Na+].O. InChi Code: InChI=1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22,,/h1-4,6,12,20H,5,19H2,(H,21,22),,1H2/q,+1,/p-1/t12-,,/m0../s1. InChi Key: IRGJMZGKFAPCCR-LTCKWSDVSA-M.