3,3',5-Triiodo-L-thyronine

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRalpha and TRbeta (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.Formal Name: O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine. CAS Number: 6893-02-3. Synonyms: L-3,3',5-Triiodothyronine, T3, Liothyronine, NSC 80203. Molecular Formula: C15H12I3NO4. Formula Weight: 651.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml. lambdamax: 227 nm. SMILES: N[C@@H](CC1=CC(I)=C(OC(C=C2)=CC(I)=C2O)C(I)=C1)C(O)=O. InChi Code: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1. InChi Key: AUYYCJSJGJYCDS-LBPRGKRZSA-N.