25-hydroxy Vitamin D2-d6

25-hydroxy Vitamin D2-d6 is intended for use as an internal standard for the quantification of 25-hydroxy vitamin D2 (Cay-12078) by GC- or LC-MS. 25-hydroxy Vitamin D2 is a metabolite of vitamin D2 (Cay-11791). It is formed from vitamin D2 by the cytochrome P450 (CYP) isoforms CYP2R1 and CYP27A1, which have 25-hydroxylase activity, and is bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream. 25-hydroxy Vitamin D2 is transported to the kidney, where it is preferentially 24-hydroxylated by CYP24A1 to produce 24,25-dihydroxy vitamin D2. It can also be hydroxylated by CYP27B1 to produce 1,25-dihydroxy vitamin D2. Serum levels of 25-hydroxy vitamin D2 have been used as a marker of vitamin D status.Formal Name: 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4-dimethyl-5-(methyl-d3)-2-hexen-1-yl-6,6,6-d3]-7a-methyl-4H-inden-4-ylidene]ethylidene]-cyclohexanol. CAS Number: 1262843-46-8. Synonyms: Ercalcidiol-d6, 25-Hydroxyergocalciferol-d6, 25(OH)-Vitamin D2-d6. Molecular Formula: C28H38D6O2. Formula Weight: 418.7. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: C=C1CC[C@H](O)C/C1=C/C=C2CCC[C@@]3(C)[C@@]\2([H])CC[C@]3([H])[C@@H](/C=C/[C@H](C)C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])C. InChi Code: InChI=1S/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25-,26+,28-/m1/s1/i4D3,5D3. InChi Key: KJKIIUAXZGLUND-SGQRFKNGSA-N. Origin: Synthetic.