2-TEDC

2-TEDC is a lipoxygenase (LO) inhibitor (IC50s = 0.09, 0.013, and 0.5 µM for 5-, 12-, and 15-LO, respectively). It prevents axon degeneration induced by withdrawal of nerve growth factor (NGF) in primary rat dorsal root ganglion neurons (mean EC50 = 2.79 µM). 2-TEDC also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp, IC50 = 7.99 µM) and reduces major capsid protein levels and virus titers in grouper spleen cells infected with Singapore grouper iridovirus when used at a concentration of 12.5 µM.Formal Name: 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 2-(2-thienyl) ethyl ester. CAS Number: 132465-10-2. Synonyms: ethyl 3,4-Dihydroxybenzylidenecyanoacetate, EDC. Molecular Formula: C16H13NO4S. Formula Weight: 315.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: OC(C=CC(/C=C(C(OCCC1=CC=CS1)=O)\C#N)=C2)=C2O. InChi Code: InChI=1S/C16H13NO4S/c17-10-12(8-11-3-4-14(18)15(19)9-11)16(20)21-6-5-13-2-1-7-22-13/h1-4,7-9,18-19H,5-6H2/b12-8+. InChi Key: KCGLTUBCAGZLHP-XYOKQWHBSA-N.