2-Iminobiotin hydrobromide

Description: 2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS, Ki of 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively). Target: NO Synthase, NOS. Smiles: [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br. References: Zitta K , Peeters-Scholte C , Sommer L , et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology, 2018, 8:971.