2-Iminobiotin

2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS, Kis = 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively). It also provides sex-specific neuroprotection against hypoxia-ischemia in neonatal rats by an NO-independent mechanism. 2-Iminobiotin has also been used to capture membrane-bound proteins through biotin-avidin interactions.Formal Name: (3aR,6S,6aS)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid. CAS Number: 13395-35-2. Synonyms: Guanidinobiotin. Molecular Formula: C10H17N3O2S. Formula Weight: 243.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: [H][C@](NC1=N)(CS[C@H]2CCCCC(O)=O)[C@@]2(N1)[H]. InChi Code: InChI=1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1. InChi Key: WWVANQJRLPIHNS-ZKWXMUAHSA-N.