2'-Deoxyadenosine-5'-O-diphosphoribose (sodium salt)

2'-Deoxyadenosine-5'-O-diphosphoribose is a transient receptor potential melastatin 2 (TRPM2) agonist. It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human TRPM2 when used at a concentration of 30 µM. 2'-Deoxyadenosine-5'-O-diphosphoribose has been found in Jurkat cells. It is also a substrate of nucleotide triphosphate diphosphatase 9 (NUDT9), a mitochondrial enzyme involved in hydrolyzing pyrophosphates.Formal Name: 2'-deoxy-adenosine 5'-(trihydrogen diphosphate), P'->5-ester with D-ribose, disodium salt. Synonyms: 2'-deoxy ADPR. Molecular Formula: C15H21N5O13P2 . 2Na. Formula Weight: 587.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: NC1=C(N=CN2[C@@H]3O[C@H](COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)([O-])=O)[C@@H](O)C3)C2=NC=N1.[Na+].[Na+]. InChi Code: InChI=1S/C15H23N5O13P2.2Na/c16-14-12-15(18-5-17-14)20(6-19-12)11-1-7(22)10(32-11)4-31-35(28,29)33-34(26,27)30-3-9(24)13(25)8(23)2-21,,/h2,5-11,13,22-25H,1,3-4H2,(H,26,27)(H,28,29)(H2,16,17,18),,/q,2*+1/p-2/t7-,8-,9+,10+,11+,13-,,/m0../s1. InChi Key: OWBODBSRHMMQRQ-AGZKKVMKSA-L.