2-deoxy-D-Glucose

2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis. It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate. 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml. In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Cay-15007) or paclitaxel (Cay-10461).Formal Name: 2-deoxy-D-arabino-hexose. CAS Number: 154-17-6. Synonyms: Ba 2758, 2-DG, NSC 15193. Molecular Formula: C6H12O5. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O[C@@H]1[C@@H](CO)OC(O)C[C@H]1O. InChi Code: InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1. InChi Key: PMMURAAUARKVCB-CERMHHMHSA-N.