2-D08

2-D08 is a synthetic flavone that inhibits sumoylation. It completely inhibits sumoylation in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM. 2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474. It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-beta (Abeta) (1-42) aggregation and Abeta-induced toxicity in PC12 cells. It also has antioxidant properties.Formal Name: 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 144707-18-6. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml, Ethanol: 1 mg/ml. lambdamax: 221, 344 nm. SMILES: O=C1C2=CC=CC=C2OC(C3=CC=C(O)C(O)=C3O)=C1. InChi Code: InChI=1S/C15H10O5/c16-10-6-5-9(14(18)15(10)19)13-7-11(17)8-3-1-2-4-12(8)20-13/h1-7,16,18-19H. InChi Key: JJAXTFSPCLZPIW-UHFFFAOYSA-N.