2'-Acetylacteoside

2'-Acetylacteoside is a phenylethanoid glycoside that has been found in C. deserticola and has diverse biological activities. It selectively inhibits aldose reductase over maltase and sucrase (IC50s = 0.071, >300, and 277 µM, respectively, for the rat enzymes). 2'-Acetylacteoside scavenges superoxide radicals in a cell-free assay and inhibits hemolysis induced by AAPH (Cay-82235) in isolated rat red blood cells in a concentration-dependent manner. It decreases glutamate-induced cytotoxicity in primary rat cortical neurons when used at concentrations of 0.1, 1, and 10 µM and protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 = 4.8 µg/ml). 2'-Acetylacteoside (10-40 mg/kg) prevents decreases in bone strength in ovariectomized mice.Formal Name: 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, 2-acetate 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]. CAS Number: 94492-24-7. Molecular Formula: C31H38O16. Formula Weight: 666.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. lambdamax: 220, 335 nm. SMILES: CC(O[C@@H]([C@@H](O[C@@H]([C@H]1OC(/C=C/C2=CC(O)=C(C=C2)O)=O)CO)OCCC3=CC(O)=C(C=C3)O)[C@H]1O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)=O. InChi Code: InChI=1S/C31H38O16/c1-14-24(39)25(40)26(41)30(43-14)47-28-27(46-23(38)8-5-16-3-6-18(34)20(36)11-16)22(13-32)45-31(29(28)44-15(2)33)42-10-9-17-4-7-19(35)21(37)12-17/h3-8,11-12,14,22,24-32,34-37,39-41H,9-10,13H2,1-2H3/b8-5+/t14-,22+,24-,25+,26+,27+,28-,29+,30-,31+/m0/s1. InChi Key: ALERZNQPBWWLMW-OMRKUVHCSA-N. Origin: Plant/Cistanche deserticola.