2,5-dimethyl Celecoxib

2,5-dimethyl Celecoxib is a derivative of celecoxib (Cay-10008672) that does not inhibit COX-2 (IC50 = >100 µM). It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 µM) and reduces prostaglandin E2 (PGE2, Cay-14010) production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 µM, respectively). It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 µM. 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.Formal Name: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 457639-26-8. Synonyms: DMC. Molecular Formula: C18H16F3N3O2S. Formula Weight: 395.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL, Ethanol: 3mg/mL. lambdamax: 256 nm. SMILES: O=S(C(C=C1)=CC=C1N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)(N)=O. InChi Code: InChI=1S/C18H16F3N3O2S/c1-11-3-4-12(2)15(9-11)16-10-17(18(19,20)21)23-24(16)13-5-7-14(8-6-13)27(22,25)26/h3-10H,1-2H3,(H2,22,25,26). InChi Key: NTFOSUUWGCDXEF-UHFFFAOYSA-N.