2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells. It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.Formal Name: 2,3-dimethoxy-5-methyl-2,5-cyclohexadiene-1,4-dione. CAS Number: 605-94-7. Synonyms: Coenzyme Q0, CoQ0. Molecular Formula: C9H10O4. Formula Weight: 182.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 268 nm. SMILES: O=C(C(C)=C1)C(OC)=C(OC)C1=O. InChi Code: InChI=1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3. InChi Key: UIXPTCZPFCVOQF-UHFFFAOYSA-N.