2',3'-Dideoxyadenosine 5'-triphosphate (lithium salt)

2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively). It also blocks, in vitro, mammalian and bacterial DNA polymerases. ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2',3'-dideoxyadenosine, competes with dATP, resulting in chain termination. Because of this activity, dideoxynucleoside 5'-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions. It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).Formal Name: 2',3'-dideoxy-adenosine 5'-(tetrahydrogen triphosphate), lithium salt. Synonyms: ddATP. Molecular Formula: C10H16N5O11P3 . XLi. Formula Weight: 475.2. Purity: >98%. Formulation: (Request formulation change), A 10 mM solution in water. Solubility: Water: soluble. SMILES: O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@@H]1CC[C@H](N2C=NC3=C2N=CN=C3N)O1.[Li]. InChi Code: InChI=1S/C10H16N5O11P3.Li/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18,/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18),/t6-,7+,/m0./s1. InChi Key: SKKDTNLQGHBADJ-UOERWJHTSA-N.