2,3-Dehydro-3,4-dihydro Ivermectin

2,3-Dehydro-3,4-dihydro ivermectin is an analog of ivermectin (Cay-18768) and an anthelmintic. It has activity against L. amazonensis promastigotes and amastigotes (IC50s = 13.8 and 3.6 µM, respectively) without inducing cytotoxicity to macrophages (IC50 = 65.5 µM).Formal Name: 2,3-didehydro-5-O-demethyl-3,4,22,23-tetrahydro-avermectin A1a. Molecular Formula: C48H74O14. Formula Weight: 875.1. Purity: >95% (mixture of diastereomers). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C3[C@@]4(O)C5=CC(C)[C@@H](O)[C@@]4([H])OC/3)=C\C[C@]6([H])C[C@@](OC5=O)([H])C[C@]7(CC[C@H](C)[C@]([C@H](CC)C)([H])O7)O6. InChi Code: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28-31,33-34,36-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,29?,30-,31-,33+,34-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1. InChi Key: AZSRBVAPBFWEGT-NAPFNFQHSA-N.