2'3'-cGAMP (sodium salt)

2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2'2'-cGAMP, 3'3'-cGAMP (Cay-17966), cyclic di-GMP (Cay-17144), and 3'2'-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively). It is a potent inducer of IFN-beta mRNA expression with an EC50 value of 19.4 nM in L929 cells.Formal Name: adenylyl-(3'->5')-2'-guanylic acid, cyclic nucleotide, disodium salt. Synonyms: 2'3'-Cyclic GMP-AMP, Guanosine-Adenosine 2',3'-cyclic monophosphate. Molecular Formula: C20H22N10O13P2 . 2Na. Formula Weight: 718.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]. InChi Code: InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33,,/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33),,/q,2*+1/p-2/t6-,7-,10-,11-,12-,13-,18-,19-,,/m1../s1. InChi Key: CNVCOPPPOWRJAV-DQNSRKNCSA-L.