2,3-bis (4-Hydroxyphenyl) Propionitrile

2,3-bis(4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor beta (ERbeta) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ERbeta (18%) versus ERalpha (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays. Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ERbeta.Formal Name: 4-hydroxy-alpha-(4-hydroxyphenyl)-benzenepropanenitrile. CAS Number: 1428-67-7. Synonyms: DPN. Molecular Formula: C15H13NO2. Formula Weight: 239.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 230, 270 nm. SMILES: NCC(Cc1ccc(O)cc1)c1ccc(O)cc1. InChi Code: InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2. InChi Key: GHZHWDWADLAOIQ-UHFFFAOYSA-N.