2-(1,8-Naphthyridin-2-yl)phenol

2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity. It enhances IFN-gamma-induced STAT1-dependent signaling, but not IFN-gamma-induced STAT3-dependent signaling or TNF-alpha-induced NF-kappaB-dependent signaling in cell-based reporter assays when used at a concentration of 45 µM. 2-NP (45 µM) increases IFN-gamma-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-gamma at the same concentration.CAS Number: 65182-56-1. Synonyms: 2-NP. Molecular Formula: C14H10N2O. Formula Weight: 222.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 215, 257, 359 nm. SMILES: OC1=CC=CC=C1C2=NC(N=CC=C3)=C3C=C2. InChi Code: InChI=1S/C14H10N2O/c17-13-6-2-1-5-11(13)12-8-7-10-4-3-9-15-14(10)16-12/h1-9,17H. InChi Key: AYKMXKNVEUMLFQ-UHFFFAOYSA-N.