(1R,9S)-(-)-beta-Hydrastine

(1R,9S)-(-)-beta-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 µM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 µM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.Formal Name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone. CAS Number: 118-08-1. Molecular Formula: C21H21NO6. Formula Weight: 383.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 299 nm. SMILES: CN1CCC2=C(C=C(OCO3)C3=C2)[C@]1([H])[C@]4([H])C(C=CC(OC)=C5OC)=C5C(O4)=O. InChi Code: InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1. InChi Key: JZUTXVTYJDCMDU-MOPGFXCFSA-N.