1A-116

1A-116 is an inhibitor of Rac1 (IC50 = 4 µM). It reduces the secretion of chemokine (C-X-C motif) ligand 5 (CXCL5), CXCL10, hepatocyte growth factor (HGF), chemokine (C-C motif) ligand 2 (CCL2), and matrix metalloproteinase-2 (MMP-2) from patient-derived acute myeloid leukemia (AML) cells when used at a concentration of 20 µM. 1A-116 (20 µM) inhibits the proliferation and migration of, and induces apoptosis in, LN-229 glioblastoma cells at 10 hours, but not 23 hours, post-synchronization. In vivo, IA-116 (3 mg/kg per day) decreases the number of lung nodules and macronodules, as well as total lung weight, in a F3II murine breast cancer model of lung tumor formation. It also inhibits the asexual replication of the P. falciparum strains D10 and W2 (IC50s = 3.21 and 6.89 µM, respectively) and sexual replication in P. falciparum 3D7 immature and mature gametocytes (IC50s = 78.13 and 56.64 µM, respectively).Formal Name: N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine. CAS Number: 1430208-73-3. Molecular Formula: C16H16F3N3. Formula Weight: 307.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: FC(F)(C1=C(NC(NC2=CC(C)=CC(C)=C2)=N)C=CC=C1)F. InChi Code: InChI=1S/C16H16F3N3/c1-10-7-11(2)9-12(8-10)21-15(20)22-14-6-4-3-5-13(14)16(17,18)19/h3-9H,1-2H3,(H3,20,21,22). InChi Key: DVIJFJSZZNOTLP-UHFFFAOYSA-N.