15-LOX-1 inhibitor 1

Description: 9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1, IC50 = 0.19 µM).1 It decreases LPS- and IFN-gamma-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 µM. 9c(i472) reduces LPS- and IFN-gamma-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 µM. Target: Others. Smiles: CCOC(=O)c1[nH]c2cc(Cl)ccc2c1\C=C\C(=O)NCc1ccccc1OC. References: Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity. J. Med. Chem. 62(9), 4624-4637 (2019).