1400W . dihydrochloride

A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd &le, 7 nM), Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki &le, 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki &le, 50 µM), Inhibits tumor growth, Increases vasoconstriction to noradrenaline, Improves contractile function, Improves stroke outcome and decreases glutamate release, Anti-inflammatory, Review.