10074-A4

10074-A4 is an inhibitor of the protein-protein interaction between c-Myc and the c-Myc associated protein Max. It inhibits c-Myc and Max heterodimerization when used at a concentration of 5 µM and reduces the proliferation of Rat1 and TGR-1 rat fibroblasts but not TGR-1 Myc knockout fibroblasts at 32 µM. 10074-A4 (32 µM) reduces the expression of the gene encoding ornithine decarboxylase (ODC), a c-Myc and Max target gene, and induces cell cycle arrest at the G0/G1 phase in Myc-overexpressing Rat1 cells. Preincubation of 10074-A4 (32 µM) with Myc-overexpressing Rat1 cells in vitro reduces tumor growth of the same cells in a mouse xenograft model.Formal Name: 3-[3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl]-2,4-thiazolidinedione. CAS Number: 312631-87-1. Molecular Formula: C18H14Cl2N2O3S. Formula Weight: 409.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 233, 240 nm. SMILES: O=C1SCC(N1CC(CN2C3=CC=C(C=C3C4=C2C=CC(Cl)=C4)Cl)O)=O. InChi Code: InChI=1S/C18H14Cl2N2O3S/c19-10-1-3-15-13(5-10)14-6-11(20)2-4-16(14)21(15)7-12(23)8-22-17(24)9-26-18(22)25/h1-6,12,23H,7-9H2. InChi Key: SCNHANGMZXFWOH-UHFFFAOYSA-N.