1-Oleoyl-2-hydroxy-sn-glycero-3-PE

1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. It induces transient increases in intracellular calcium in PC12 rat neuronal cells in a concentration-dependent manner, an effect that can be blocked by the lysophosphatidic acid receptor 1 (LPA1) antagonist AM095 (Cay-22141). 1-Oleoyl-2-hydroxy-sn-glycero-3-PE (100 ng/ml) increases IL-2 production in CD1d-stimulated murine natural killer T (NKT) cell hybridoma 2H4 cells. It also induces production of IL-4, but not IFN-gamma, in murine splenocytes when used at a concentration of 100 ng/ml and in mouse serum when administered at a dose of 1 µg per animal, indicating induction of the T helper 2 (Th2) response. 1-Oleoyl-2-hydroxy-sn-glycero-3-PE levels increase in interscapular brown adipose tissue (iBAT) in mice following three-day cold exposure.Formal Name: 1-oleoyl-2-hydroxy-sn-glycero-3-phosphatidylethanolamine. CAS Number: 89576-29-4. Synonyms: 18:1 LPE, 18:1 Lyso-PE, 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine. Molecular Formula: C23H46NO7P. Formula Weight: 479.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 3 mg/ml. SMILES: O[C@@H](COP(OCC[NH3+])([O-])=O)COC(CCCCCCC/C=C\CCCCCCCC)=O. InChi Code: InChI=1S/C23H46NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(26)29-20-22(25)21-31-32(27,28)30-19-18-24/h9-10,22,25H,2-8,11-21,24H2,1H3,(H,27,28)/b10-9-/t22-/m1/s1. InChi Key: PYVRVRFVLRNJLY-MZMPXXGTSA-N. Side Chain Carbon Sum: 18:1.