1-Deoxygalactonojirimycin (hydrochloride)

1-Deoxygalactonojirimycin is a competititve inhibitor of alpha-galactosidase (IC50 = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to alpha-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes. Pharmacological chaperones, including 1-Deoxygalactonojirimycin, are used to promote lysosomal delivery of unstable proteins in lysosomal storage disorders, like Fabry disease.Formal Name: (2R,3S,4R,5S)-2-(hydroxymethyl)-3,4,5-piperidinetriol, monohydrochloride. CAS Number: 75172-81-5. Synonyms: DGJ, Migalastat. Molecular Formula: C6H13NO4 . HCl. Formula Weight: 199.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 314 nm. SMILES: O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)NC1.Cl. InChi Code: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3,/h3-11H,1-2H2,1H/t3-,4+,5+,6-,/m1./s1. InChi Key: ZJIHMALTJRDNQI-OLALXQGDSA-N.